What malignancy is characterized by the enlargement of lymph nodes and a deficiency of the immune response?

Hodgkin's Disease, also known as Hodgkin lymphoma, is characterized by the abnormal growth of lymphocytes that leads to the enlargement of lymph nodes, known as lymphadenopathy. One of the hallmark features of this malignancy is the presence of Reed-Sternberg cells which are large, abnormal cells that indicate the disease's pathology. As the condition progresses, it can lead to suppression of the immune system, contributing to a deficiency in immune response, making the body more susceptible to infections and other diseases.

The other options do not describe the same disease process: Hemoglobinopathy refers to disorders related to the structure or production of hemoglobin, not lymph node pathology. Gas gangrene is an infection characterized by muscle tissue death, typically due to certain types of bacteria, and does not involve lymphatic malignancy. Immunodeficiency refers to a state where the immune system's ability to fight infections is compromised but does not specifically encompass the lymphadenopathy characteristic of Hodgkin's Disease. Thus, Hodgkin's Disease is the specific condition that directly correlates with both lymph node enlargement and immune response deficiency.