Which type of bone cancer arises from connective tissue?

Osteosarcoma is the type of bone cancer that arises specifically from connective tissue. This cancer originates in osteoblasts, which are the cells responsible for bone formation, making it a primary bone malignancy. Osteosarcoma typically occurs in the long bones, especially around the knee, and is most common in teenagers and young adults. The aggressive nature of this cancer often leads it to develop rapidly, and understanding its origin helps in diagnosis and treatment.

In contrast, osteomalacia refers to the softening of bones caused by a deficiency of vitamin D, which affects bone mineralization rather than being a type of cancer. Osteogenesis imperfecta is a genetic disorder characterized by brittle bones due to a lack of collagen, but it is not a cancer. Osteoporosis, on the other hand, is a condition where bones become weak and brittle due to bone density loss, rather than the formation of malignant tumors. Therefore, osteosarcoma is distinct in that it is a malignancy arising from connective tissue, making it the correct answer.